Umbilical Vein Endothelial Cells Expression of Adhesion Molecules by Human Factor Xa Induces Cytokine Production and
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Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells.
Proinflammatory effects induced by the serine protease factor Xa were investigated in HUVEC. Exposure of cells to factor Xa (5-80 nM) concentration dependently stimulated the production of IL-6, IL-8, and monocyte chemotactic protein-1 (MCP-1) and the expression of E-selectin, ICAM-1, and VCAM-1, which was accompanied by polymorphonuclear leukocyte adhesion. The effects of factor Xa were blocke...
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تاریخ انتشار 1998